Chemical denervation and selected ganglionectomy studies have shown that loss of sympathetic or sensory innervation induces remarkable changes in the nerves that remain...
Following chronic guanethidine sympathectomy there is complete depletion of sympathetic cotransmitters NA and NPY from the dura mater but an increase in the the expression of NPY in non-sympathetic axons (lacking small dense covered vesicles) supplying cerebral vessels and the iris. (Mione et al. 1990). The source of increased cerebrovascular NPY is thought to be preexisting parasympathetic cranial ganglia...(Gibbins and Morris 1988).
Indeed, sympathectomy-induced increased DBH-immunoreactivity in the sphenopalatine (parasympathetic) ganglion occurs at the same time as a loss in VIP-immunoreactivity (Fan and Smith 1993). In the cerebral artery and uterine artery, loss of sympathetic nerves also leads to increased DBH-immunoreactvity in non-sympathetic nerves that lack TH and NA (Morris et al. 1987); Mione et al. 1991)
In the lung, sympathectomy induces a marked increse in CGRP-immunoreactive nerve density around the airways, blood vessels and also in the vicinity of the neurepithelial bodies of the pulmonary epithelium (Van Ranst and Lauweryns 1990).
page 110,
| By Otto Appenzeller, P. J. Vinken, G. W. Bruyn, |
| Contributor Otto, Appenzeller, P. J. Vinken, G. W. Bruyn |
| Published 2000 Elsevier Health Sciences |
| Autonomic nervous system / Pathophysiology |
