sympathectomy can relieve symptoms of angina

Surgical sympathectomy can relieve symptoms of angina in patients with refractory angina. However, in these high-risk patients this thoracic surgery may result in significant morbidity and mortality rates.

Clinical Investigations

American Heart Journal. 133(6):648-655, June 1997.
Gramling-Babb, Patricia MD; Miller, Michael J. MD; Reeves, Scott T. MD; Roy, Raymond C. MD; Zile, Michael R. MD
http://pt.wkhealth.com/pt/re/amhj/abstract.00000406-199706000-00007.htm;jsessionid=L6WWlJ0hBkQfdvQ9pgYwy1mHSyrL4pcGKTw5PvNGJSgDFD1j8L3V!1270838445!181195628!8091!-1

disturbed peripheral vascular and heart rate responses

Thoracic sympathectomy can result in reduced sweating and disturbed peripheral vascular and heart rate responses. Patients should be warned that these mechanisms may play a role in the development of exertional heat stroke.

Is Previous Thoracic Sympathectomy a Risk Factor for Exertional Heat Stroke?
http://www.ncbi.nlm.nih.gov/pubmed/17720429

Abnormal stress responses in patients with diseases affecting the sympathetic nervous system

Patients who lack baroreceptors have exaggerated blood pressure responses to stress. They have episodes of hypertension and hypotension that cause headaches and dizziness.

Patients with diseases of the sympathetic nervous system illustrate that everyday occurrences such as a change in posture or ambient temperature are stresses requiring a marked change in sympathetic nervous activity. Both physical and psychological stresses elicit large initial sympathetic neuronal responses that are subsequently damped by feedback inhibition from structures such as the baroreceptors. Damage to part of these feedback loops leads to exaggerated pressor responses to stress.
Ziegler MG, Ruiz-Ramon P, Shapiro MH.

University of California, San Diego.

Psychosom Med. 1993 Jul-Aug;55(4):339-46.

complex alterations of vascular reactivity

Enhanced vascular reactivity in the sympathectomized rat: studies in vivo and in small isolated resistance arteries.

Conclusions: In conclusion, we showed that sympathectomy produces complex alterations of vascular reactivity both in vivo and in isolated vessels, which shift the balance of the sensitivity of the vessel between vasoconstrictor and vasodilating agents towards an increased constriction. These results are unlikely to simply reflect denervation supersensitivity; their underlying receptor, post-receptor and/or contractile mechanisms are yet to be identified.

Journal of Hypertension. 18(8):1041-1049, August 2000.
Rizzoni, Damiano 1; Perlini, Stefano 2,3; Mircoli, Luca 2; Porteri, Enzo 1; Franzelli, Cristina 2; Castellano, Maurizio 1; Rosei, Enrico Agabiti 1; Ferrari, Alberto U. 2,4

Abnormal pain following nerve sprouting

Collectively, our findings indicate that as a result of autonomic sprouting due to CCI of the MN, remaining intact nociceptive fibres may potentially develop sensitivity to sympathetic and parasympathetic stimulation, which may have a role in the generation of abnormal pain following nerve injury.

---

Received 22 October 2004, revised 17 February 2005, accepted 23 February 2005

C. Grelik ¹ , G. J. Bennett ^3,4,5 and A. Ribeiro-da-Silva ^1,2,5

¹ Department of Pharmacology & Therapeutics, McGill University, 3655 Prom. Sir-William-Osler, Montreal, Quebec, Canada H3G 1Y6
² Department of Anatomy and Cell Biology,
³ Department of Anesthesia,
⁴ Faculty of Dentistry, and
⁵ McGill Centre for Research on Pain, McGill University, Montreal, Quebec, Canada

Summary from the University of Cambridge

ANDBN, MAGNUSSON and ROSENGREN (1965)
have demonstrated a complete loss of DOPA decarboxylase activity of iris, spleen
and submaxillary gland after surgical sympathectomy, and a complete loss of tyrosine
hydroxylase activity of heart, submaxillary gland and kidney has been found after
surgical sympathectomy (POOL, COVELL, LEVITT, GIBB and BRAUNWALD, 1967;
SEDVALL and KOPIN, 1967; NAGATSU, RUST and DE QUATTRO, 1969). Although the
time course of the fall in DOPA decarboxylase and tyrosine hydroxylase activities
of operated vasa was not investigated, a preliminary experiment showed that all
DOPA decarboxylase activity was absent one day after denervation. Thus, it seems
likely that these two enzymes which are involved in the biosynthesis of NA have
a cellular localization within the sympathetic nerves of the vas deferens.
NORADRENALINE METABOLIZING ENZYMES IN
NORMAL AND SYMPATHETICALLY DENERVATED
VAS DEFERENS
B. JARROTTI and L. L. IVERSEN
Department of Pharmacology, University of Cambridge, Cambridge, England
(Received 5 May 1970. Accepted 21 May 1970)

Sympathectomy causes diminished capacity for physical sensation

Results: In the hot-plate analgesia test, sympathectomized rats increased their hot-plate latency time compared with that of sham-operated rats. Density of calcitonin gene-related peptide immunoreactive fibers in sympathectomy side of the lumbar dura mater decreased to 45.5% compared with the contralateral side. The number and size of calcitonin gene-related peptide immunoreactive cells in dorsal root ganglia showed no difference between sympathectomized and contralateral side.

Conclusion: Sympathectomy increased the pain threshold and made the sympathectomized rats hypesthetic.

An Anatomic Study of Neuropeptide Immunoreactivities in the Lumbar Dura Mater After Lumbar Sympathectomy.

Spine. 21(8):925-930, April 15, 1996.
Sekiguchi, Yasufumi MD *+; Konnai, Yasunobu MD *+; Kikuchi, Shinichi MD, PhD *; Sugiura, Yasuo MD, PhD +

Long-term superior cervical sympathectomy induces mast cell hyperplasia and increases histamine and serotonin content

Nerve fibres and mast cells are often described in close morphological and functional interactions in various organs such as the dura mater. The respective roles of mast cell activation and sympathetic impairment in cluster headache and migraine attacks have been repeatedly suggested. We have thus investigated the long-term effects of sympathectomy on mast cell morphology and content in the rat dura mater.
After unilateral ganglionectomy, the histamine content increased progressively and significantly 30–60 days post-surgery in both hemi-dura, whereas the serotonin content became significantly different from that of sham only 60 days post-surgery in the ipsilateral dura. After bilateral ganglionectomy, the histamine level significantly increased in both hemi-dura 15–60 days post-surgery, whereas the serotonin level had significantly increased at 60 days post-surgery.

These results clearly demonstrate, for the first time, a long-term trophic effect of sympathetic nerve degeneration on mast cells in the dura mater.

A. Bergerot^*, A. -M. Reynier-Rebuffel^†, J. Callebert^‡ and P. Aubineau

Copyright © 1999 IBRO. Published by Elsevier Science Ltd.

Mast cell hyperplasia: role of cytokines.

Bischoff SC, Sellge G.

Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Germany

Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast cell progenitors circulate in peripheral blood and subsequently migrate into the tissue where they undergo final maturation under the influence of local microenvironmental factors. Cytokines are of particular importance for mast cell recruitment, development, and function. Stem cell factor (SCF) is a unique mast cell growth factor, since mast cells disappear completely in the absence of SCF. However, several other cytokines such as IL-3 and IL-4 have been shown to influence mast cell proliferation and function also. This review focuses on the role of cytokines in the regulation of mast cell hyperplasia. Copyright 2002 S. Karger AG, Basel

Int Arch Allergy Immunol. 2002 Feb;127(2):118-22.